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Obesity and other ill-effects of Iodine deficiency

Obesity and other ill-effects of Iodine deficiency

More Nutritional Articles

Obesity and other ill-effects of Iodine deficiency

Arkansas Nutrition and Natural Healing

Dr. Roger Trubey, Dr.PH, MPH, and Doctor of Integrative Medicine 362 Unger Trail, Mountain Home, Arkansas 72653

Call 501-538-4944

Obesity and other ill-effects of Iodine deficiency

Obesity and other ill-effects of Iodine deficiency

If you were asked to name some of the most important nutrients for you body, chances are that one of your suggestions would not be iodine.  In fact it rarely rates any mention at all when one is asked to name as many nutrients as they can.  And it never even rates a consideration when listing the nutrients most deficient in the American diet.  And why should it?  We use iodized salt, so we’re covered, right?  Unfortunately in almost every case the answer is no.  At least 8 and probably 9 out of ten individuals are deficient (some very deficient) in this critical nutrient.  Iodine deficiency is widespread and may play a role in breast and ovary cancers, thyroid disorders, fibromyalgia, arrhythmia, diabetes, fatigue, chronic infections and obesity…all very common problems in western society.

David Brownstein, MD, in his practice has tested over 4,000 patients and his results have been quite consistent – over 95% of his patients were iodine deficient.  Guy Abraham, MD, agrees and considers the problem so widespread that he says we have an epidemic of iodine deficiency in this country.

During the last 3-4 decades, iodine levels have fallen by nearly 50%.  During this same time period there has been an increasing number of patients complaining of symptoms consistent with under-functioning thyroid (hypothyroid) and auto-immune thyroid disorders.   If you think hypothyroidism may not be too common, consider the symptoms:  fatigue, weakness, dry skin, cold intolerance, low body temperature, headaches, weight gain, depression, constipation, brittle nails elevated cholesterol and many others….typical symptoms in any practitioner’s daily office schedule.

Among the components necessary for a healthy functioning thyroid, iodine has to rank near the top.  Without it, thyroid function and metabolism will be impaired.  This will affect the burning of fat for energy and heat.  Perhaps it is not coincidental then, that the epidemic of obesity parallels the epidemic of iodine deficiency and especially is this true during the last 35 years.  It is also of interest to note that during this same period more toxic and competitive halogens, such as bromine, fluorine, chlorine and chlorine compounds, have significantly increased in our environment and have found their way into our food, water and medicinals.  These compounds competitively inhibit iodine absorption, promote an iodine deficiency and replace iodine stores in fat cells, where they block the release of fat and inhibit weight loss.  This effect on weight loss is considered by some to prevent weight loss beyond a certain point.  A plateau is reached in the weight loss endeavor and patients feel incapable of a further reduction in weight.

So why is iodized salt not enough for us?  Well, keep in mind many people avoid salt or reduce its consumption.  But even when freely used in the diet, there is over 30,000 times (on a molar basis) more chloride than iodine ions in iodized salt.  Remember the competitive problem I mentioned earlier?  (Think also of Splenda®– where chlorine is complexed to the sugar molecule)  Now it only takes a very small amount of iodine to prevent a goiter, .05mg/day, but we need much more than that to successfully operate a thyroid gland and complete all the other projects found in the iodine job description.  It is in fact, found in every organ and tissue of the body but especially in the thyroid, liver, lung, heart and adrenals.  Its highest concentration appears to be in fat and muscle tissues, however.  And yet the daily iodine intake levels set by the WHO (World Health Organization) were recommended with the goal of prevention of simple goiter and not for nourishing the whole body with the amount of iodine all the other tissues might need.  Consider that only 20 – 30% of total body iodine is found in the thyroid gland.

The conventional approach to treating hypothyroidism is the use of synthetic drugs.  However the long-term use of these synthetic drugs such as Synthroidtm, is associated with a depletion of tissue iodine levels.  It would only make sense then to recommend that iodine/iodide should always be used with these drugs.

The work of Drs. Abraham and Brownstein has shown that iodine, the universal nutrient, has at least 5 major functions overall:

    1.  Weight Regulation, Hormonal Function and Energy

Thyroid hormones must have adequate iodine to function properly.  These hormones that use iodine, simulate an increase in the number and size of the mitochondria – the cellular site for the production of energy.  This will directly affect the overall metabolic rate in the body.  But the thyroid hormone is also involved with the metabolism of fats and carbohydrates, heart rate and the strength of the heartbeat, muscle and gastrointestinal function, digestion, gene transcription and directly influences other endocrine hormones. In essence most every area of the body is affected by our thyroid function or lack thereof.

Without sufficient iodine, thyroid hormones will dysfunction, which leads to a deficient metabolism and inadequate fat burning for energy and heat.  In addition it will be accompanied by a difficulty losing or maintaining previously lost weight.  No surprise to anyone with the ability to see, we have an epidemic of obesity in this country.  One of the reasons for this is that iodine is crucial for metabolism and weight loss.  Iodine and other toxic halogens will store in our fat cells and when the other halogens, like chlorine are excessive, they inhibit the function of iodine which facilitates the release of fat from the cell.  Do keep in mind, however, that iodine is no magic pill in your weight loss endeavor, if you are not following a correct eating and exercising program.

    1.  Immune Function

Individuals with inadequate iodine levels are prone to infections of all types.  You remember putting iodine on an open wound?  Well, it naturally has anti-bacterial, anti-viral and even anti-parasitic properties.  In sufficient amounts it has been found to induce a destruction of cancer cells and iodine deficiency is associated with increased risk for cancers and cysts.  Finally, one of iodine’s least appreciated roles is its ability to act as a natural detoxifier of mercury, fluorides, chlorides and bromides.

    1. Fertility and Menstrual Function

Probably due to its concentration and role in the thyroid, breasts and ovaries, iodine deficiency has long been associated with difficulty in conceiving.  But it is more commonly involved with menstrual irregularities, fibrocystic breasts, ovarian cysts and possibly early menopause and prostatitis in men.  Dr. Brownstein believes that iodine deficiency is a major cause of breast cancer and other diseases of the reproductive organs.

    1. Brain Development and Function

Iodine and thyroid hormone deficiency will have a marked impact on intelligence and memory and is likely to play a significant role in learning disabilities and attention deficit disorders.  Iodine is also found in the eye and in the substantia nigra area of the brain – the area associated with Parkinson’s disease.  Even breast milk has (or is supposed to have) high amounts of iodine since this nutrient is very important for brain and nervous system development in children.

    1.  Heart and Arrhythmias

Like underactive thyroid, heart arrhythmias are nearly epidemic.  Adequate iodine levels are necessary for a smooth regular heartbeat.  One of the more common drugs used to treat arrhythmia, Amiodarone, is primarily iodine in a sustained-release, but toxic form.  But caution here – it is not safe to use iodine along with Amiodarone – do consult with your physician first.

It was in the 1920s that iodine was first added to table salt.  As noted earlier, this practice gave a false sense of iodine sufficiency.  The medical community relied 100% on iodized salt instead of the previously used forms of iodine and iodide found in Lugol Solution (a 5% solution of 50mg iodine and 100mg potassium iodide per milliliter).  Rarely used since the 1950s, Lugol Solution provided twice the amount of iodine present in table salt (which also has none of the important potassium iodide form), and none of the competing chlorine ions.

So instead of adding or re-supplying the iodine, physicians relied on synthetic drugs (such as Synthroid) to treat patients with thyroid deficiency.  However there are many individuals who have 50 –80% or more of the symptoms of thyroid deficiency but have “normal” thyroid hormone levels, and none of these receive any treatment at all.  This is the classic Wilson’s Syndrome.  Those suffering with this syndrome always have low body temperature and have difficulty staying warm.  Which is why the late, Broda Barnes, MD, always found the basal body temperature (97.8 or lower suggestive of hypothyroid) a better indicator of thyroid function than that of blood thyroid levels. Yet there are a number of practitioners who feel they could substantially improve (if not cure) these Wilson’s Syndrome individuals as well as a very high percentage of those with classical hypothyroid or hyperthyroid conditions by normalizing iodine levels.

The thyroid gland, fat tissue, and some other vital organs appear to be repositories of toxic metals, such as mercury, along with other toxic contaminants. When this occurs, organ dysfunction is likely.  One of the benefits of iodine is that it facilitates increased removal and excretion of poisons from these tissues.  In addition it enhances the liver’s detoxification mechanisms.  Perhaps this is why Dr. Abraham discovered that even patients with a complete thyroidectomy benefited from iodine therapy.  He found that some of his patients who achieved iodine sufficiency were able to resolve diabetes without insulin and to normalize blood pressure with a reduction or elimination of their medication.

Testing for Iodine Sufficiency – home test

Here is a simple test to determine whether an iodine deficiency exists.  From a bottle of tincture of iodine (drug stores carry these), paint a 2 inch square area on your inner arm.  If it disappears in less than 8 hours, iodine need is indicated.

Testing for Iodine Sufficiency – lab test

A more definitive way of testing for iodine deficiency uses a pre and post urine evaluation.  Testing first involves collecting urine immediately upon arising for the spot or pre-test.  After this collection, 50 mg. of potassium iodide/iodine is ingested and then all urine passed in the next 24 hours is collected and measured, with a sample sent to the lab for analysis. In essence the more iodine found in the urine, the less the body needs.  Likewise, the less of the ingested iodine sample found in the urine, the more the body wanted the iodine and the greater the deficiency and need for supplementation.  If the body has sufficient iodine at least 90% will be excreted in the urine.  Supplementation is normally done rather gradually as iodine can mobilize toxic metals and other toxic poisons from storage sites in sufficient quantities to provoke symptoms.  Re-testing should be repeated no later than 3-4 months to ensure successful therapeutic results.

In regards to supplementation, keep in mind that nearly all available supplements found in health food stores or pharmacies contain only the iodide form of iodine.  However, Drs. Brownstein, Flechas, Abraham and others found that to successfully improve iodine levels in the body, it was necessary to include both the iodide (reduced) and iodine (oxidized) forms because the body needs both forms. The iodine content of food is extremely variable, but the richest food sources all come from the ocean – Kelp/seaweed, sea vegetables, sea bass, cod, haddock, and ocean perch.  Several of these may be a significant source of mercury as well.

It is highly unlikely for excess iodine intake to occur when following the recommended dosage schedule and following urine testing results.  But in very rare cases of excess, individuals may experience a metallic taste, increased salivation, sinus headache, nervousness, palpitations and a sense of fever, all easily rectified by adjusting the amount of iodine.  It should be noted, however, that some symptoms thought to be due to excess iodine, may in fact be the forced excretion of those toxic metals and compounds lodged in the tissues.

Summary       

When you put the whole picture together and compare our country with Japan, you have to ask, “What is the consequence of the Japanese ingesting many, many times the amount of iodine as the average American?”  And the answer is (at least in part), a much leaner population, a significantly lower rate of breast cancer, a lower infant mortality rate and a much better life expectancy.   Of course there are other factors but let us not forget, Iodine is a part of that improved health.

The need is to achieve whole body sufficiency of iodine.  When this state is reached it correlates well with overall well being.  Energy levels go up, sleep improves and less is required, elimination is better and skin complexion is much healthier.  The following results have been noted by one doctor:

* Goiters reduced/eliminated
* Elevated TSH readings lowered to normal
* Thyroid gland excretes toxins and other heavy metals
* Improvement of the liver’s detoxification mechanism
* Improvement in weight management
* Improved blood sugar and blood pressure regulation
* Improved menopausal symptoms
* Breast tissue normalization including fibrocystic breast disease
* Ovary tissue normalization of polycystic ovary syndrome
* Less brain fog and clearer thinking
* Heart function improvement with reduced arrhythmias
* Reduction of thyroid and breast cancer rates

Candida Yeast Nutrition Support Protocol

Candida Yeast Nutrition Support Protocol

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Candida Yeast Nutrition Support Protocol

Arkansas Nutrition and Natural Healing

Dr. Roger Trubey, Dr.PH, MPH, and Doctor of Integrative Medicine 362 Unger Trail, Mountain Home, Arkansas 72653

Call 501-538-4944

Factors That Encourage Yeast Overgrowth

Yeast overgrowth can be triggered by a number of things. These include a high-sugar, high trans-fat, low-fiber diet, impaired immunity, use of drugs like antibiotics, birth control pills, estrogen, and steroids like prednisone, and psychological stress.

Frequent use of antibiotics disrupts the normal balance between healthy bugs in the gut (lactobacillus, bifidobacter, E. coli) and other potentially dangerous bugs, including yeasts, bacteria and occasionally parasites. These bad bugs are usually present in small numbers in the digestive system. But when the good bugs are killed by antibiotics or not fed with adequate fiber or the bad guys are fueled with too much sugar, or the gut’s delicate ecosystem is damaged by too much stress, then yeasts and other noxious agents take over.

For many individuals it is the load of toxic heavy metals (mercury, lead etc) in the gut that encourages yeast overgrowth.  Get a toxic metal evaluation – at least 2/3 of individuals have serious heavy metal toxicity.

Dietary Recommendations:

    • Avoid all sugars including honey, fructose corn syrup.  Replace sugar with Xylitol or Stevia.
    • Omit all dried fruits (raisins, dates etc), pineapple, tropical fruits (including pineapple) melons and all fruit juices.  Limit other fruits to one per day.   Vegetable juice is perfectly fine
    • Avoid all refined carbohydrates especially those made with yeast – such as bread, bagels, muffins – and all cereal and pasta made with white flour, white rice and corn.
    • For most people consuming fewer grains will improve their health.  But when used, by all means select whole grain sources – whole wheat, brown rice etc.
    • Most root (starchy) vegetables, including potatoes, convert to sugar quite rapidly and should be avoided.  Sweet potatoes (without the brown sugar) can be an exception.   Peanuts and peanut butter are very often contaminated with mold and should be avoided.
    • Choose lean, quality protein at each meal such as chicken/turkey breast (organic when available), lean beef (grass-fed beef is highly recommended), fish (wild, not farmed, Alaskan salmon, sardines, cod etc), eggs and whey protein.  You want to increase the amount of omega 3 fatty acids found in cold water fish as above but also found in a limited amount in flaxseed, walnuts and pumpkin seeds.
    • Limit or best to omit, all foods with Trans fats, hydrogenated vegetable oils, margarine and shortening.  Cook with olive or coconut oil.
    • Use 5 or more servings of vegetables daily which can include green drinks.
    • Drink at least 2 quarts of pure water , add a couple of cups of green tea and no alcoholic beverages
    • Good snacks are nuts, celery with almond butter, healthy protein bars and boiled eggs.

Supplement Considerations

• Oregano — Oil of oregano has many antibacterial and antifungal properties.
• Garlic — Fresh, crushed garlic is a potent antimicrobial and immune booster.
• Grapefruit seed extract — The phytochemicals in citrus seeds have been found to have potent antimicrobial properties.
• Berberine — This potent yellow plant extract comes from goldenseal and barberry
• Tannins — These are the astringent compounds found in tea and the bark of trees.
• Undecylenate — This chemical compound is a potent antifungal.
• Isatis tinctoria — This Chinese herb can be a useful adjunct to treating intestinal imbalances.
• Caprylic acid — This is another useful compound for treating yeast.

Probiotics – Take at least 10 to 20 billion live organisms a day of lactobacillus and bifidobacter species.   A special “yeast against yeast” probiotic called saccharomyces boulardii (Florestor) can be very safe and effective in controlling yeast and often by itself – but don’t take any of the above supplements with it.

Charcoal and Fiber – You should also consider taking two to three activated charcoal capsules every four to six hours during the day or a soluble fiber supplement that contains guar gum, alginates, psyllium seed, or pectin to bind to yeast toxins and facilitate their natural release.

Symptoms of Yeast overgrowth

Although symptoms of yeast overgrowth are similar to those of many other conditions, you may have a yeast problem if you have these problems:


General Symptoms

Please Note:    The overgrowth of yeast in the intestinal track will often lead to an increase of intestinal permeability which in turn leads to (among other things) food allergies or sensitivities.  Many symptoms of Candidiasis are very similar to symptoms of food sensitivities.   You may need to consider the very good possibility of a food sensitivity problem if the yeast problem is a chronic one.  Check with your health care professional to determine the differences and appropriate therapeutic solutions

• Chronic fatigue
• Loss of energy
• General malaise
• Decreased libido

Gastrointestinal Symptom
• Thrush
• Bloating and gas
• Intestinal cramps
• Rectal itching
• Altered bowel function such as diarrhea or constipation
Genitourinary Symptoms
• Yeast infections
• Frequent bladder infections
• Interstitial cystitis (irritable bladder)
Hormonal Complaints
• Menstrual irregularities like pain, bleeding, etc.
• Premenstrual syndrome
• Thyroid dysfunction

Nervous System Complaints
• Depression
• Irritability
• Inability to concentrate

Immune System Complaints
• Allergies
• Chemical sensitivities
• Low immune function

Past History
• Chronic yeast infections
• Chronic antibiotic use for infections or acne
• Oral birth control pill usage
• Oral steroid hormone usage

Associated Conditions
• Sensitivity to foods, chemicals, or other allergens
• Eczema
• Psoriasis
• Irritable bowel syndrome
• Craving for foods rich in carbohydrates or yeast

The above information is not intended as a substitute for your health care provider.  It is not intended as a means to cure, treat, prevent, diagnose or mitigate any disease.  For all medical problems you should consult your primary care provider.  You can use this support information to support his/her evaluation and treatment as per their discretion

Cyrex Array #2-#5

Cyrex Array #2-#5

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Cyrex Array 2: Intestinal Antigenic Permeability Screen

A test that identifies how gluten is robbing you of gut health

 

 

Arkansas Nutrition and Natural Healing

Dr. Roger Trubey, Dr.PH, MPH, and Doctor of Integrative Medicine 362 Unger Trail, Mountain Home, Arkansas 72653

Call 501-538-4944

Gluten causes inflammation in the gut, which can eventually lead to intestinal permeability, or “leaky gut.” Leaky gut allows undigested food particles, bacteria, and other pathogens to escape into the bloodstream where they can trigger allergies, sensitivities, and inflammation in other parts of the body.  This test pinpoints which of these is causing leaky gut so your practitioner knows what to specifically target for faster and more efficient gut repair.

We evaluate:

  • Actomyosin IgA                           Lipopolysaccharides (LPS) IgG
  • Occludin/Zonulin IgG                 Lipopolysaccharides (LPS) IgA
  • Occludin/Zonulin IgA                 Lipopolysaccharides (LPS) IgM
  • Occludin/Zonulin IgM

Array 2 is an antibody assessment of the intestinal barrier integrity and bacterial endotoxins (lipopolysaccharides), tight-junction proteins (occludin, zonulin) and cell cytoskeleton (actomyosin) and identifies both transcellular (through the cells) and paracellular (between the cells) routes of intestinal barrier penetration (leaky gut) by large molecules with a capacity to challenge the immune system.
Gluten causes inflammation in the gut, which can eventually lead to intestinal permeability, or “leaky gut.” Leaky gut allows undigested food particles, bacteria, and other pathogens to escape into the bloodstream where they can trigger allergies, sensitivities, and inflammation in other parts of the body. This is a main reason why people come back sensitive to many foods.  Several different mechanisms cause leaky gut:

  • Breakdown of cells
  • Loosening of the junctures of the gut lining
  • Bacterial, Viral or Parasite infection

This test pinpoints which of these is causing leaky gut so your practitioner knows what to specifically target for faster and more efficient gut repair.    Price: $295.00

Paracellular penetration of Antigens

Transcellular penetration of Antigens

TRANSCELLULAR & PARACELLULAR ROUTES OF INTESTINAL BARRIER PENETRATION:

Cyrex Array #2-#5Cyrex Array 3: Wheat/Gluten Proteome Sensitivity and Autoimmunity

More than one wheat protein can cause Gluten Sensitivity – Cyrex Labs tests for multiple peptides of gluten
Being Gluten Sensitive isn’t as black-and-white as once thought.  Actually, gluten is a misnomer – “gliadin” is the portion of wheat that triggers an immune response in people (since “gluten” is commonly used I will stick with that term).  It also has been discovered that wheat is made up of more than 100 different components that can cause a reaction, not just one (gliadin).
Array # 3 test for the following:

Wheat IgG                                          Wheat IgA                                                         Wheat Germ Agglutinin IgG
Wheat Germ Agglutinin IgA             Native + Deamidated Alpha-Gliadin-33-mer IgG
Native + Deamidated Alpha-Gliadin-33-mer IgA                                                     Alpha-Gliadin-17-mer IgG
Alpha-Gliadin-17-mer IgA                 Gamma-Gliadin-15-mer IgG                         Gamma-Gliadin-15-mer IgA
Omega-Gliadin-17-mer IgG               Omega-Gliadin-17-mer IgA                           Glutenin-21-mer IgG
Glutenin-21-mer IgA                           Gluteomorphin+Prodynorphin IgG           Gluteomorphin+Prodynorphin IgA
Gliadin-Transglutaminase IgG           Gliadin-Transglutaminase IgA                    Transglutaminase-2 IgG
Transglutaminase-2 IgA                      Transglutaminase-3 IgG                               Transglutaminase-3 IgA
Transglutaminase-6 IgG                      Transglutaminase-6 IgA

 

Being Gluten Sensitive isn’t as black-and-white as once thought.  Actually, gluten is a misnomer – “gliadin” is the portion of wheat that triggers an immune response in people (since “gluten” is commonly used I will stick with that term).  It also has been discovered that wheat is made up of more than 100 different components that can cause a reaction, not just one (gliadin).
Until now testing for Gluten Sensitivity has only been against one of those components, alpha gliadin. Through extensive research Cyrex pinpointed the twelve components of wheat that most often provoke an immune response.

This new test greatly expands the parameters of gluten sensitivity testing, catching those who may have previously tested negative because they don’t react to the alpha gliadin. A ‘false negative’ occurs when the test results says a condition is not present, when in reality there is a problem.  Many forms of standard testing for celiac disease or gluten sensitivity do not include the right markers or enough of the right markers.  Using Cyrex Array 3 allows for more accurate results with fewer ‘false negatives’.

The test is recommended for individuals who have:

  • Non-responsive intestinal complaints including irritable bowel syndrome and colitis
  • Chronic, multiple system complaints, including chronic fatigue syndrome and fibromyalgia
  • Depression, any type of auto-immunity, neurological conditions including ADHD and Parkinson’s
  • Chronic anemia  and skin conditions such as rosacea, eczema and psoriasis and canker sores
  • Headaches and migraines, and hormonal problems including infertility and PMS
  • other illusive complaints and conditions for which no answers are given

 

Opioid testing

Array 3 screens for antibodies to the opioids produced from wheat called Gluteomorphins and Prodynorphins.  Gluten can have a drug-like opiate effect on an individual.  Antibodies to gluteomorphin and prodynorphin can indicate that gluten is affecting your brain.  Some people have enzymes in their digestive tract that break gluten down into opioids that act like heroin or morphine.  Embarking on a gluten-free diet can cause terrible withdrawal symptoms in these people.  One practitioner tells of a patient whose withdrawal symptoms were so severe she went to the emergency room.
Another problem with opioids is they disrupt brain function by attaching to receptor sites normally meant for neurotransmitters.  Neurotransmitters are brain chemicals that help dictate our personality, moods, behavior, bodily function, and more.
This opioid effect on neurotransmitter receptors explains why gluten plays a role in so many cases of ADD/ADHD, autism, or behavioral problems in children; or brain fog, depression, anxiety, schizophrenia, anorexia and migraines in adults.  When one mother put her autistic son on a gluten-free diet, he began eating the binding out of books as he was so desperate for his gluten-opioid “fix.”

Lectins

Array 3 also includes testing for antibodies to the wheat lectin Wheat Germ Agglutinin (WGA).  WGAs are lectins or carbohydrate-binding proteins with a capacity to bind to many cells and tissue antigens.  Lectins can bind to cells involved in the immune system and induce toxic damage, inflammation and autoimmunity.

Enzymes

Array 3 includes testing for antibodies to enzymes:  Tissue Transglutaminases -2, -3 and -6 and Gliadin-Tranglutaminase Complex.  Transglutaminases are a family of enzymes that form protein polymers, like scaffolding, which are vital in the formation of barriers and stable structures such as gut tissue.  Antibodies may appear in serum before the clinical onset of symptoms.

Gliadin-Transglutaminase IgG can assist with diagnosing Celiac Disease.

Tissue Transglutaminase-2 (tTG2) is commonly recognized for being an effective diagnostic test for celiac disease.  Transglutaminase is an enzyme in the digestive tract targeted in an autoimmune attack triggered by gluten. tTG2 antibodies indicate gluten is attacking gut tissue through an autoimmune attack.

Tissue Transglutaminase-3 (tTG3) is express mainly in the epidermis (skin disorders) and to a lesser extent in the placenta and the brain.

Tissue Transglutaminase-6 (tTG6) is expressed in neural tissue.  tTG6 may be involved in the pathogenesis of gluten reactivity-related neurological dysfunction.
Price: $425.00

 

Cyrex Array 4: Gluten-Associated Sensitivity and Cross-Reactive Foods

In cross-reactivity, the body may mistake another food for gluten and react accordingly.  Array 4 tests for 24 different foods that may be causing cross-reactivity or are newly introduced to the diet or over-consumed favorites.
One of the most frustrating scenarios for both the practitioner and the patient is when a gluten-free diet fails to have any effect on a person who seems so clearly gluten sensitive. Newer research shows this may be due to cross-reactivity.  In cross-reactivity, the body mistakes another food for gluten and reacts accordingly.  Array 4 tests for 24 different foods that may be causing cross-reactivity or are newly introduced to the diet or over-consumed favorites.   Array #4 Tests for the following Foods:

 

  • Rye, Barley, Spelt, Polish Wheat IgG + IgA Combined
  • Cow’s Milk IgG + IgA Combined
  • Alpha-Casein & Beta-Casein IgG + IgA Combined
  • Casomorphin IgG + IgA Combined
  • Milk Butyrophilin IgG + IgA Combined
  • Whey Protein IgG + IgA Combined
  • Chocolate (Milk) IgG + IgA Combined
  • Oats IgG + IgA Combined
  • Yeast IgG + IgA Combined
  • Coffee IgG + IgA Combined
  • Sesame IgG + IgA Combined
  • Buckwheat IgG + IgA Combined
  • Sorghum IgG + IgA Combined
  • Millet IgG + IgA Combined
  • Hemp IgG + IgA Combined
  • Amaranth IgG + IgA Combined
  • Quinoa IgG + IgA Combined
  • Tapioca IgG + IgA Combined
  • Teff IgG + IgA Combined
  • Soy IgG + IgA Combined
  • Egg IgG + IgA Combined
  • Corn IgG + IgA Combined
  • Rice IgG + IgA Combined
  • Potato IgG + IgA Combined

 

One of the most frustrating scenarios for both the practitioner and the patient is when a gluten-free diet fails to have any effect on a person who seems so clearly gluten sensitive. Newer research shows this may be due to cross-reactivity.  In cross-reactivity, the body mistakes another food for gluten and reacts accordingly.  Array 4 tests for 24 different foods that may be causing cross-reactivity or are newly introduced to the diet or over-consumed favorites.
Dairy – Cross-reactivity is common with dairy as its structure so closely resembles that of gluten.  In fact 50% of people who are sensitive to gluten are also sensitive to dairy.  This panel has great clinical significance as it can explain why people still react even after giving up gluten and dairy.     Price: $325.00

The test is recommended for individuals who:

  • Have non-celiac Gluten sensitivity or celiac disease
  • Are experiencing limited improvements or are non-responsive on a gluten-free diet
  • Have gut dysbiosis, which appears to be resistant to standard therapy
  • Suspect that other foods may be involved in causing them to feel unwell
  • Were found to have significant “leaky gut” problems on the Array #2, Intestinal Antigenic Permeability Screen

 

Cyrex Array #2-#5

Cyrex Array 5: Systemic Autoimmune Reactivity Screen

Which parts of the body are affected by a gluten-sensitivity?

People typically shrug off the possibility of gluten sensitivity by saying, “I don’t have any digestive problems.”  Little do they know that gluten produces digestive symptoms in only a minority of people (1 out of 8).  For the majority, gluten can damage other tissue or organs like the brain, the heart, the skin or the respiratory tract.

Array #5 tests for the following ongoing damage to the following tissues and organs:

 

  • Parietal Cell + ATPase IgG + IgA Combined
  • Intrinsic Factor IgG + IgA Combined
  • ASCA + ANCA IgG + IgA Combined
  • Tropomyosin IgG + IgA Combined
  • Thyroglobulin IgG + IgA Combined
  • Thyroid Peroxidase (TPO) IgG + IgA Combined
  • 21 Hydroxylase (Adrenal Cortex) IgG + IgA Combined
  • Myocardial Peptide IgG + IgA Combined
  • Alpha-Myosin IgG + IgA Combined
  • Phospholipid IgG + IgA Combined
  • Platelet Glycoprotein IgG + IgA Combined
  • Ovary/Testis* IgG + IgA Combined
  • Fibulin IgG + IgA Combined
  • Collagen Complex IgG + IgA Combined
  • Arthritic Peptide IgG + IgA Combined
  • Osteocyte IgG + IgA Combined
  • Cytochrome P450 (Hepatocyte)
  • IgG + IgA Combined
  • Insulin + Islet Cell Antigen
  • IgG + IgA Combined
  • Glutamic Acid Decarboxylase 65 (GAD 65)
  • IgG + IgA Combined
  • Myelin Basic Protein IgG + IgA Combined
  • Asialoganglioside IgG + IgA Combined
  • Alpha + Beta Tubulin IgG + IgA Combined
  • Cerebellar IgG + IgA Combined
  • Synapsin IgG + IgA Combined

 

People typically shrug off the possibility of gluten sensitivity by saying, “I don’t have any digestive problems.”  Little do they know that gluten produces digestive symptoms in only a minority of people (1 out of 8).  For the majority, gluten can damage the brain, the heart, the skin, the respiratory tract or the joints.

Cyrex Array 5 can be useful for Patients who:

  • Have been diagnosed with an autoimmune disorder, as they commonly develop additional autoimmune conditions
  • With chronic increased intestinal permeability, which is the gateway for environmentally-induced autoimmune disorders
  • Chronic increased intestinal  permeability (Array #2), which is the gateway for  environmentally-induced autoimmune disorders

The Cyrex Array 5 is an economical and effective way to assess possible tissue damage to multiple organs of the body and will help you assess predictive antibodies.  Elevated numbers of antibodies, known as Predictive Antibodies, are measurable up to ten years before the clinical onset of the disease. Identification of pathogenesis at this stage allows for the possible arrest or even reversal of disease progression.

 Array 5 – Systemic Autoimmune Reactivity Screen™ looks at multiple tissues commonly targeted by auto-antibodies, including heart, thyroid, joint, gut, brain, liver, thyroid, ovaries, bone and more.     Price: $675.00

Gluten Sensitivity Disease

Gluten Sensitivity Disease

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The Following Diseases Have Been Directly Associated with Gluten Sensitivity.

Those diagnosed with these conditions may benefit tremendously by being genetically tested for gluten sensitivity.

 

Arkansas Nutrition and Natural Healing

Dr. Roger Trubey, Dr.PH, MPH, and Doctor of Integrative Medicine 362 Unger Trail, Mountain Home, Arkansas 72653

Call 501-538-4944

The following is a list of very common manifestations. Below is a more detailed list:

• Asthma
• Hypothyroid
• Ezcema
• Psoriasis
• Autism
• ADD/ADHD
• Colic
• Schizophrenia
• Bipolar
• Irritable Bowel Syndrome
• Infertility
• Chronic Constipation
• Iron deficiency anemia
• Osteoporosis
• High Cholesterol
• Non alcoholic fatty liver disease
• Fibromyalgia
• Chronic Fatigue syndrome

• Angina Pectoris (chest pain/pressure)
• Anorexia
• Immunoglobulinopathies
• Antiphospholipid syndrome
• Anxiety
• Apathy
• Apthous ulcers and canker sores
• Aortic Vasculitis
• Arthritis
• Juvenile rheumatoid
• Enteropathic
• Psoriatic
• rheumatoid

• Abdominal pain and distention
• Spontaneous abortion
• Addison’s Disease
• ADHD
• Alopecia (hair loss)
• Anemia (can be caused by the following nutrient deficiencies)
• Iron deficiency
• Folate deficiency
• B-12 deficiency
• B-6 deficiency
• Vitamin C deficiency
• Vitamin E deficiency
• Copper deficiency
• Ataxia
• Atherosclerosis
• Autism and other learning disorders
• Cholangitis (gall bladder)
• Dermatitis Herpetiformis
• Autoimmune hepatitis
• Polyglandular syndrome

• Thyroiditis (hypothyroidism)
• Bitot’s spots
• Blepharitis
• Abnormal blurry vision
• Bone pain
• Bone fractures
• Cachexia
• Bronchiectasis
• Bronchoalveolitis
• Adenocarcinoma of the intestine
• Small cell esophageal cancer
• Melanoma
• Asthma
• Cardiomegaly
• Cardiomyopathy
• Cataracts
• Cerebral perfusion abnormalities
• Cheilosis
• Chorea
• Coagulation abnormalities
• Crohn’s disease
• Ulcerative colitis
• Chronic constipation
• Coronary artery disease
• Diarrhea
• Lymphoma
• Cutaneous vasculitis
• Cystic fibrosis
• Delayed puberty
• Failure to thrive
• Dementia
• Depression
• Dermatomyositis
• Diabetes Mellitus type I (shares the same HLA genes as Celiac disease)
• Down syndrome
• Dysmenorrhea
• Dysgeusia
• Duodenal erosions
• Edema
• Eczema
• Dysphagia
• Epilepsy
• Spontaneous nose bleeds
• Erythema nodosum
• CFS
• Growth retardation
• Mental retardation
• Secondary food allergy response
• Blood in the stool
• Gastric bloating
• Grave’s disease
• Bleeding gums
• Hair loss
• Heartburn
• H. pylori infection
• Hives
• NAFL
• Malnutrition and nutritional deficiencies
• Infertility
• Hypogonadism
• Hypoglycemia
• Hypospenism
• Thrombocytopenia

• Impotence
• Osteoporosis
• Insomnia
• IBS (irritable bowel syndrome)
• Keratomalacia
• Lactose intolerance
• Loss of smell
• Non Hodgkin lymphoma
• Early menopause
• Migraine headache
• Multiple sclerosis
• Muscle wasting
• Myopathy
• Obesity
• Osteomalacia
• Osteopenia
• Parathyroid carcinoma
• Pancreatic insufficiency
• Polymyositis
• PMS
• Biliary cirrhosis
• Psoriasis
• Dermatitis
• Sjogren’s syndrome
• Short stature
• Scleroderma
• Steatorrhea
• Spina bifida
• SLE
• Tremors
• Parkinson’s disease
• Glossitis

• Vitiligo
• Vomiting
• Vaginitis
• UTI

Dangerous Mycotoxins – what you need to know

Dangerous Mycotoxins – what you need to know

New Articles

Dangerous Mycotoxins – what you need to know

Arkansas Nutrition and Natural Healing

Dr. Roger Trubey, Dr.PH, MPH, and Doctor of Integrative Medicine 362 Unger Trail, Mountain Home, Arkansas 72653

Call 501-538-4944

 

During the last couple of decades, practitioners in the field of Natural or Functional medicine are seeing more and more patients with a complex set of symptoms that never seem to lead to a good diagnosis of anything specific – just a random set of possibilities.  Conventional doctors, equally puzzled, just continue to prescribe one drug after another for symptomatic relief, but never of course, getting to any of the underlying causes.

And for many patients those underlying factors could well be from several potential sources.  I find it rather common to see, chronic, low-level, “flying under the radar” viral and bacterial pathogens, chemical toxins, food sensitivities, gastrointestinal dysfunctions and nearly always genetic abnormalities with specific variants or mutations in critical genes and gene pathways.  Conventional medicine rarely looks for these primal or root dysfunctions and then dismisses many a patient as a hypochondriac.

Some individuals feel they are having an optimal lifestyle – eating organic, healthy foods, exercising, managing stress, and getting their 8 hours of sleep, yet they still have a lot of nagging symptoms and their doctor visits are not producing any answers or improvement. The fatigue remains along with those recurring headaches and nasal issues.  There are others but with the memory problems they can’t remember them all.

But there is another intrinsic cause, often overlooked even by practitioners in Functional Medicine – that being patients dealing with mold/mycotoxin illness.  And it is true… it can be difficult to recognize as it will masquerade as many other illnesses, with lots of vague symptoms and nothing specific.  Mold and mycotoxin illness can range from flu-like feelings that do not go away to serious illness and a nightmare type of fatigue with brain fog that makes everyday tasks nearly impossible.  It is even more challenging when you consider that conventional medicine doesn’t really believe that mold exposure is a problem at all.   But first, what are molds and mycotoxins anyway?

Nasty Mold – Hazardous Mycotoxins

Molds are multiple types of fungi that grow in filaments and reproduce by forming tiny spores that sprout and fly away but are invisible to the naked eye. Mold grows in damp, warm, and humid locations, inside and outside.  But obviously can grow in your refrigerator as well.

mold

We have all seen mold on bread or an orange that took too long for us to consume.  But that is not what is most concerning.  The real problem is mold that we cannot see.  And some individuals can be exposed to serious levels of mold without realizing it.  It can be hiding inside walls, around water pipes that have leaked, around bathtubs that overflowed or in our air conditioning systems.

 

I once had a patient who came to see me with a variety of strange symptoms that to me was suspicious of mold/mycotoxin illness.  Because it began shortly after moving into an older home, I suggested she have it checked for a source of mold.

She indicated it was thoroughly investigated by a home inspector as a part of the sale.  I strongly encouraged her to have it re-examined.  She did and the inspector almost missed it.  But when he opened the duct directly above her bed it looked something like this:

Dangerous Mycotoxins – what you need to know

She had lived there for two years, breathing toxic mold for 8 hours/night.  But here’s the problem.  While we may either remove ourselves from the mold or remove the mold contamination from our homes, the mycotoxins produced by the mold remain in us indefinitely until we have them cleared from our body.  Unfortunately, that is not done by just taking a nice little supplement because it is a more complex task, often taking several months.   But, when this is the problem they are dealing with, removal of mycotoxins in our body is critical if one is to ever get well,.

 

And here is something else that few individuals realize.  It has been estimated that 25% of the world crops are contaminated from mold and fungal growth.  From orange juice to most coffee to peanuts and legumes and very, very commonly in nearly all grains and cereals.  Fungal and mold contamination is the most commonly occurring natural contaminate in our foods.  And yes, even many organic foods.

Dr. Amy Myers, a very experienced mold/mycotoxin practitioner, describes mycotoxins this way: “Mycotoxins are very toxic compounds given off by certain types of mold. Molds are all around us and the vast majority of them are not dangerous. However, there are some molds that produce gas-like substances called mycotoxins. These are very similar to a volatile organic compound (VOC).”

Dangerous Mycotoxins – what you need to know

Some individuals are more sensitive to mold and mycotoxin exposure than others.  It has to do with their genetic predisposition.  Individuals with variants or mutations to the HLA-DR gene, and other genes that control inflammation are not able to successfully rid their body of these mycotoxins.  It may be as high as ¼ of the population that are at risk due to these gene variants.  It is not a problem for them if exposure does not take place, but if it does, they can be seriously affected.

And yes, it is also true that one could be affected even without those variants in the HLA-DR gene.  Just having a good deal of inflammation in one’s body with a genetically compromised ability to counteract that inflammation and poor detoxification in our intestine, liver and kidneys can set us up for trouble as well.

Symptoms of Mycotoxin illness

The most common symptom of mycotoxin illness is fatigue, but secondarily, headache. However, individuals will have other symptoms specific to their genetics and biochemical makeup. Here is what to look for:

 

Immune Symptoms

 

  • Fatigue or Chronic fatigue syndrome
  • Autoimmune disease
  • Fibromyalgia/Joint pain
  • Fever

 

Respiratory Symptoms

 

  • Nasal symptoms/sinusitis
  • Chronic cough/ throat irritation
  • Weak voice or wheezing
  • Asthma/allergies
  • Air hunger/chest discomfort

 

Neurological Symptoms

 

  • Memory problems
  • Headaches
  • Slurring of speech
  • Insomnia
  • Lightheaded
  • Brain fog/spaciness
  • Depression/anxiety
  • Difficulty concentrating
  • Focus issues/ADD-ADHD
  • Symptoms of Lyme disease

 

 

Skin Symptoms

 

  • Rash
  • Heat or cold intolerance
  • Numbness
  • Skin slushing
  • Eczema

 

Digestive Symptoms

 

  • Bloating
  • Food sensitivities
  • Leaky gut
  • Recurrent yeast infections

 

Eye Symptoms

 

  • Watery eyes
  • Visual changes

 

Musculoskeletal Symptoms

 

  • Spasms
  • Joint pain
  • Coordination problems
  • Weakness

 

Seeing this list of symptoms might give you an understanding of why mycotoxin illness is considered the great masquerader and look terribly similar to Lyme, Fibromyalgia, Chronic Fatigue Syndrome, and Autoimmune diseases.

It is also sadly true that many a breast implant, when removed, has serious mold contamination growing on those implants inside women’s bodies, contaminating them with these dangerous mycotoxins.  The truly tragic factor – it rarely ever discovered until one undergoes explant surgery.  But by then the damage has been done.  And because either mold growth or chemical contamination takes years to develop, most women and their doctors fail to link present-day symptoms with a many year’s earlier implant surgery

Other symptoms are also possible.  As many will experience flu-like illness or a general ill feeling with things just not being right in the brain.  Long-term exposure, these dangerous mycotoxins can damage the immune system, the liver, kidney, hormonal balance, skin, and brain.  As you can see, they can have a serious and powerful effect on human health

Dr. Daniel Amen, a Psychiatrist, has this to say about the effect of mycotoxins on the brain: “…it damages people’s brain and if damages their brain, they look like they have ADD.  The look depressed.  They’re having trouble of getting along, being successful.”

Indeed, the effect on the brain can be serious.  Notice what another highly qualified mold/mycotoxin physician, Dr. Jill Carnahan, has to say of the effect of mycotoxins on the brain.

  • T-2 toxin – Known for inducing neuronal cell death in both fetal and adult brains.
  • Macrocyclic trichothecenes – Causes neuronal cell death and inflammation in the olfactory system.
  • Fumonisin B1 (FB1) – Causes neuronal degeneration in the cerebral cortex and disrupts ceramide synthesis (and important lipid in the brain).
  • Ochratochin A (OTA) – Induces acute depletion of striatal dopamine, which has shown to cause cell death in the hippocampus, substantia nigra, and striatum (different parts of the brain).

I suspect that for some individuals, long-term exposure to mycotoxins may be a major factor in their dementia and Alzheimer’s disease – although, clearly not excluding a number of other factors.  But mycotoxins love the brain as a place to call home

You see, mycotoxins have a serious impact on your mitochondria, our cells engine, that create the energy for the cell to function, including brain cells.  Because mitochondria are in nearly every cell of your body, mycotoxin damage to those powerplants will affect the function of nearly every organ and system of our body – fatigue being the obvious one.  But the damage will produce free radicals that act like cellular rust producing inflammation everywhere, eventually leading toward autoimmune-type diseases.

 

Now for some good news

The good news is that it is entirely possible to clear your body and your environment of mycotoxins and to prevent toxic mold from growing out of control in your home and mycotoxins in your body.  But the first step is to see if you have been exposed to mold and are experiencing mycotoxin illness.

I have had patients tell me that they do not recall any mold exposure previously.  But when test results come back and it shows elevated antibodies to specific mycotoxins, they are surprised to see that.  When I review possible sources of exposure with them, invariably we will discover the likely source.

For one patient it was working in a musty gymnasium that had a leaky roof.  For another it was a house she rented that was also not adequately sealed from rainwater.  But there are a myriad of other sources and the first and foremost treatment is to either remove oneself from the source or remove the source, and completely clear up all damaged and contaminated material – usually destroying and replacing it, and having it done professionally.

But for many individuals they may have long ago removed themselves from a mold contaminated building, but their health issues remain because they didn’t know that they took their mycotoxins with them, and no one has helped them to clean up their internal damage along with those persistent mycotoxins.

Testing

Testing for mycotoxins can be done via blood or urine.  Because our food supply, such as nuts, cereals, and rice are contaminated by mold, but even meat, fruits, nuts, wine, beer, coffee as well, for that reason, mycotoxins can be found in the urine in parts per billion in healthy people.  So, the preferred method of testing is blood IgG and IgE as this gives me the indication of what your body perceives as threats

 

Blood tests for mycotoxins have been used for the last 20 years and are highly accurate.  The specificity and sensitivity of blood serum testing for the presence of antibodies to mycotoxins in the blood are extremely high.  The test I use is for IgG and IgE antibodies for 12 mycotoxins for a total of 24 test results. These include Mycotoxins from:

 

  • Penicillium (mycophenolic acid)
  • Alternaria
  • Aspergillus (gliotoxin)
  • Stachybotrys
  • Cladosporium
  • Aspergillus auto-toxin
  • Aspergillus/Penicillium neurotoxic mycotoxin
  • Ochratoxin
  • Satratoxin
  • T-2 Toxin
  • Vomitoxin
  • Verrucarin and verrucarol

 

So, if you find your symptom picture matching several the symptoms above and you have not found a solution, give some thought to mycotoxin illness as something you should consider and then get tested.

 

And as usual, these statements have not been evaluated by the Food and Drug Administration. The products mentioned in this article are not intended to diagnose, treat, cure, or prevent any disease.   The information in this article is not intended to replace any recommendations or relationship with your physician.

Dr. Trubey’s patients with digestive conditions routinely obtain relief from Irritable Bowel Syndrome, Chronic gastritis, and chronic diarrhea. Call for an appointment – 501-538-4944.

 

Those Amazing Peptides – Are they the missing component to improve your Health?

Those Amazing Peptides – Are they the missing component to improve your Health?

New Articles

Those Amazing Peptides – Are they the missing component to improve your Health?

Arkansas Nutrition and Natural Healing

Dr. Roger Trubey, Dr.PH, MPH, and Doctor of Integrative Medicine 362 Unger Trail, Mountain Home, Arkansas 72653

Call 501-538-4944

 

What are Peptides?

Peptides are short chains of amino acids.  Amino Acids are the natural building blocks of proteins.  Our bodies use these peptides as signaling molecules for biological pathways to initiate activity in those pathways.  The use of peptides as a supplement will help stimulate these same functions and in the same way that naturally occurring peptides will have in those target areas

Our body is completely familiar with peptides as it uses them for many biological functions.  Their effects are specific and generally without side-effects as they are naturally found throughout our body and their metabolic pathways are already in place.

Supplemental peptides are bio-identical, having the exact structure of peptides already created by our own body, but sometimes due to diet indiscretions or genetics, they are in inadequate amounts for necessary optimal function.  Supplementation bridges this gap, promoting optimal function.

 

Those Amazing Peptides – Are they the missing component to improve your Health?

 

The body uses a vast array of highly specific signaling peptides to regulate different functions of tissues throughout the body. Thus, peptide therapy offers the potential to achieve specific responses of select tissues rather than less precise and broad effects of hormone therapy or trying to achieve a desired effect by altering physiologic processes with medications.

 

In addition, many commonly used peptides have been found to have no side effects even when given at doses 1000 times the usual dose, which is unheard of with any medication.

 

Peptides control and modulate most systems in your body, including hormone production, immune function, the sleep cycle, the production of inflammatory mediators, DNA replication, cell division and renewal, cancer cell destruction and apoptosis, libido and sexual arousal, weight loss, lean muscle gain, mitochondrial function, cognitive function, mood, energy and other metabolic activities, tissue healing and specific biological functioning of the brain, skin, eyes, urinary and reproductive systems, aging and longevity, and many more.

  • Peptides regulate most every known process and system in the body
  • Peptide therapies generally have tissue-specific effects while hormones have less precise with broad effects
  • Shown to be extremely safe
  • Most peptides are the same as naturally produced in the body but a few are synthetically produced

 

 

The categories of Peptides and where they work

 

  • Immune & thymic modulating peptides
  • Brain peptides
  • Sleep supporting peptides
  • Growth hormone secretagogue peptides
  • Antimicrobial peptides
  • Rejuvenation & pain reducing peptides
  • Mitochondrial & energy enhancing peptides
  • Melanotropic (melanin/tanning) peptides

 

 

Thymic peptides

Our thymus gland is intimately involved in immune activation.  The function of the thymus cannot be overstated.  Yet its function begins to slowly decrease throughout our 20s and 30s and reaches its lowest level of activity in our early 40s – about the time we start to see the onset of chronic degenerative diseases in many individuals.  Thymic function stays at

About 10% of our peak production (early in life) for the remainder of our lives.  This results in some unfortunate consequences for us, including:

 

  • Increased susceptibility to infections
  • Inadequate immune response to vaccinations
  • Increased cancer risk
  • Increased cardiovascular disease
  • Increased autoimmune and degenerative diseases

 

Using thymic peptides practitioners have found that these marvelous peptides will:

  • Modulate the immune response to produce a balanced immune system, particularly reducing any inflammatory proinflammatory cytokines or enhancing them as needed individually
  • Providing significant repair, restoring, and healing activity
  • Improving the function of the mitochondria with increased ATP or energy production
  • They directly support cellular function and induce normal gene function
  • Stimulation of wound healing, and proper stem cell function and proliferation
  • Stimulation of white blood cell activity and the removal of toxins and waste material from the cell
  • They work to support and maintain a healthy GI mucosa and blood brain barrier. This works to protect against a leaky gut and a leaky brain – keeping unwanted toxic material out of the blood and the brain
  • Calms excessive inflammation in the brain from overactive microglial cells and binding or blocking neurotoxins, endotoxins and electromagnetic toxins
  • They improve Natural Killer cell production – critical to our immune system

One of those Thymic peptides being used by clinicians, Thymosin Beta 4 Fragment, is composed of only 4 amino acids; yet that little peptide fights excess clotting (often seen in chronic disease), is anti-inflammatory, supports cellular healing and stimulates the production of blood vessels.  But it’s wide-ranging activity is also known to do the following:

 

  • Lowers inflammation
  • Gut repair
  • Induces autophagy
  • Calms muscle spasm/ cardiac injury
  • Improved muscle tone
  • Increased exchange of substances between cells
  • Encourages tissue repair
  • Stretches connective tissue
  • Helps maintain flexibility
  • Reduced inflammation of tissue in joints
  • Encourages the growth of new blood cells
  • Increased endurance and strength
  • Promotes hair growth

 

  • Protects and supports liver
  • Antiviral/ kills Lyme cysts – herpes
  • Skin repair/healing
  • Balances immune-regulatory system
  • Prevents the formation of adhesions and fibrous bands in muscles, tendons, and ligaments
  • promotes cardiomyocyte migration, survival, and repair, and the pathway it regulates may be a new therapeutic target in the setting of acute myocardial damage.

 

 

In addition, doctors have found it helpful as a restorative and regenerative therapy for neurological injury and degenerative diseases.  That would include a great number of these health problems

Of further interest is that in animal studies, the use of thymic and pineal gland peptides was found to increase the maximum lifespan in those animals when compared to control animals.  In addition, they were found to have stronger immune systems with reduced rates of cancer

 

Sleep peptides

One lifestyle habit of so many in the western world is not giving themselves adequate time to sleep – cutting the time of sleep sometimes on both ends.  For others it is just a problem with insomnia – they would like to sleep but can’t.  And yet one of the most important needs for our health is adequate sleep, 7-9 hours daily.  So, it may not be surprising then that a couple of the sleep peptides are having a profound impact on the individuals using them.  The benefits improve the levels of neurotransmitters as well as melatonin and the benefits that naturally come with improved deep sleep.  These include:

  • Increase in pineal gland synthesis of serotonin and melatonin
  • Increases in telomere length (increase in telomere length equates to longer life)
  • Reduced ageing of the reproductive system and increases fertility in older female rats
  • Improves T4 to T3 conversion of thyroid hormones (inactive to active)
  • Improves glucose tolerance and decreases insulin resistance
  • Slows aging and increases longevity
  • Protects against senescent cells (cells that are no longer dividing) and cancer
  • Activates gene expression and protein synthesis in specific tissues

One physician suggested that these may be “one of the best anti-aging substances we know of”, and here is why.

 

These two peptides were investigated over a 6–8 year period in 266 elderly patients and were only treated in the first two to three years of the study.  The results showed convincingly of their ability to normalize basic functions of the human organism.  The effects seemed to be protracted long after their use was discontinued, resulting in a 2-2.4 fold decrease in acute respiratory disease incidence, reduced incidence of clinical manifestations of ischemic heart disease, hypertension, deforming osteoarthritis and osteoporosis as compared to controls.

 

A separate group of patients was treated with peptides annually for the entire 6 years and their mortality rate was ¼ that of the control group

The Delta Sleep Inducing Peptide (DSIP) is a neuropeptide discovered by the Swiss during the 1970’s. DSIP has been found in various areas throughout the body such as the hypothalamus and the pituitary glands.

This is a really interesting compound which mainly aids in helping sleep disorders. However, it’s still being studied nearly 40 years after its initial discovery.  The most common use for DSIP is as a sleep aid which allows for deeper sleep. However, this isn’t some over the counter supplement like melatonin or some herbal tea. This peptide is on a whole other level.

Most users report having a massive improvement in memory function throughout the day.  This is likely because the 3rd and 4th stages of sleep is where our brain begins to do the most repair work. This is also the critical time when the brain sifts through our experiences through the day and ‘cleans out the hard drive’ to decide what to keep and discard from our memories of that day. DSIP is often paired with another peptide to gain the maximum sleep effect

Having the proper quality of sleep allows for proper healing and repair for our brain. This peptide has been shown to allow those suffering from poor sleep to perform cognitive tasks much better.

Also, keep in mind that much of our growth hormone is released by the pituitary gland during sleep. So, one could theorize an increase in GH output and healing due to these deeper sleep patterns.

Remember, while the growth hormone is essential for the growth of children. In adults it is involved in the repair functions of the body.  In addition, it is during our deep sleep that the cleansing of brain toxins take place.

So, with the use of these peptides and improved sleep, one might expect to see:

  • Deceases cortisol levels
  • Stimulates the release of luteinizing hormone (LH)
  • Increases the release of Grow Hormone
  • Releasing Hormone (GHRH)
  • Normalizes blood pressure
  • Studies in mice have suggested that it could have antioxidant effects
  • Shown to have anti-carcinogenic properties by reducing tumor sizes in mice
  • People with major depressive disorders were shown to have significantly lower levels of DSIP.
  • This suggest that DSIP could help with depression.
  • Experiments suggest that DSIP could be helpful in treating alcohol and opiate dependency.
  • Research is being carried out to use DSIP as a treatment for sleeping disorders such as narcolepsy and insomnia.

Not everyone will benefit from this peptide and studies have found this to be true.  Thus, it may be that when combined with other modalities a more positive experience may be realized.  So, some practitioners combine DISP with Epitalon or another peptide, CJC, an analogue of growth hormone.

 

Body Protection Compound peptide

One of the most commonly used peptides used by Functional doctors is the Body Protection Compound.  This jewel of a peptide, of only 15 amino acids, seems to make every other natural healing modality just work better.

 

It was originally discovered and isolated from human gastric juice and strangely, is resistant to breaking apart even in the gastric juice.  It is known to have a wide range of healing modalities, including supporting the production of nitric oxide modulating neurotransmitter levels, and having positive effects toward the intestinal microbiome, the gut-brain axis and protecting against leaky gut.   However, the benefits may extend to include, gastritis/GERD, gastric ulcers, SIBO and food intolerances.

 

In addition, this BPC peptide improves cardiovascular function and is protective against the toxic effects of EMFs.  The medical literature indicates it having benefits in:

 

  • Heart failure
  • Hypotension or hypertension
  • Post heart attack cardiac damage
  • Arrhythmias and vascular repair

 

In the nervous system practitioners and researchers have found it beneficial in the treatment of central and peripheral nervous system pathologies, including:

 

  • Traumatic brain injury
  • Alzheimer’s disease
  • Parkinson’s disease
  • Peripheral nerve damage

 

  • Mood disorders including anxiety and depression

 

The Body Protection Compound assists the body in the repair of tendons, muscles, intestines, and bones – all of the areas where so many individuals are dealing with chronic symptoms and not seeming to improve.  If you have a hard time with wound healing, we can certainly call on this peptide for assistance and expect to be helped.

Brain peptides

Many practitioners are finding that our brain is benefited with nutritional supplements called Neuotrophins or nootropics.  Nootropics are compounds or supplements that enhance cognitive performance.  Some docs use this term for so-called smart drugs.

 

The identification of new compounds with neurotrophic properties is becoming a new strategy for the prevention and/or treatment of neurodegenerative disorders.  One of these peptides, Cerebrolysin, is currently approved for use in 44 countries as a treatment for dementia and stroke.  Research studies and its use in medical practice has revealed:

  • It is indeed a neurotropic with repair properties
  • Penetrates the blood brain barrier and is neuroprotective
  • Stimulates both the central and peripheral nerve growth factors
  • Has been found to be very helpful in autism and Asperger’s syndrome at very low doses
  • It has been found beneficial for traumatic brain injury, Alzheimer’s, and stroke patients

 

Other nootropic peptides have also been found to have similar activities, but will also

  • Shield neurons from neurotoxins, inflammation and injury
  • Protect against stress effects and depression
  • Seems to benefit learning and memory function
  • Interact with and support a balanced neurotransmitter function
  • Works to regenerate neurological damage in Parkinson’s, stroke, Alzheimer’s, and toxin induced brain dysfunction

 

 

Many functional health practitioners are seen an increasing number of patients having symptoms of mast cell activation.

Mast cell activation is an immunological condition in which mast cells, a type of white blood cell, inappropriately and excessively release chemical mediators, resulting in a wide range of chronic symptoms, which can be as severe as anaphylaxis or near-anaphylaxis attacks, but more likely include flushing, itching, diarrhea, shortness of breath, brain fog, skin lesions, joint swelling hives and many others.

 

Primary organ system involved include cardiovascular, dermatological, gastrointestinal, neurological and respiratory systems.  Because of their nature it can cause a lot of anxiety and panic in individuals affected.

 

Several of the peptides have immune modulating activity and will calm down excessive stimulation of these cells.  Even one of the Melanocortins, KPV, and one of the rejuvenating/pain peptides are potent immune modulators, reducing inflammation and inhibiting this mast cell activation, while promoting a healing response.

 

Beyond the mast cell activity reduction, they tend to stimulate weight loss, reduce insulin and leptin resistance.  But they go even deeper in their activity, enhancing restful sleep and gut health, lowering depression, while lessening risk of elevated blood sugar

 

More on KPV

This relatively newer tripeptide is an alpha melanocyte-stimulating hormone. New research on hormones in this class have shown immunomodulating and anti-inflammatory effects of these peptides. KPV has a multitude of uses on the auto-immune side as well as the anti-inflammatory side

KPV works very well as a topical cream for things such as acne, eczema and psoriasis. In an oral form, it can help with ulcerative colitis, irritable bowel syndrome, and Crohn’s disease, but also for:

 

  • Cystic acne
  • Acne in general
  • Crohn’s disease
  • Ulcerative colitis
  • Irritable bowel syndrome
  • Eczema
  • Psoriasis
  • Mold
  • Lyme
  • Potential help with multiple sclerosis
  • inflammatory skin and eye conditions
  • allergic asthma
  • arthritis
  • decreases Mast cell activation

 

  

Peptides for sexual health

One area of health that some are reluctant to discuss but is a problem in a huge percentage of adults of both sexes, is that of dysfunctional sexual health.  It can be a problem not just in the geriatric population but is now being seen in young adults as well.

Turning to the PDES inhibitor drugs like Viagra or Cialis is helpful only for some men but not for women.  The most common complaints are of erectile dysfunction and loss of libido.  In fact, in the older pool of premenopausal women, approximately 6 million suffer from hypoactive sexual desire.  But if I were making a guess on this, my bet would be that that figure is much, much higher.  And for that group of women the melanocortin peptide PT-141, should be given a try.

 

With close to 20 million males affected by ED, this peptide is well worth a trial run.  Many men report a dramatic improvement to their ED.

 

The PT-141 peptide has been helpful to both men and women and works by activating your dopamine hormone to enhance sexual performance and motivation.  Unlike Cialis or Viagra, which works on the nitric oxide level in the vascular system, this peptide acts on the nervous system, via activation of the neurons in the hypothalamus to increase sexual desire, with a rather high rate of success in both males and females, providing users the following:

 

  • Increase in libido levels
  • Elevated degrees of sexual gratification
  • Enhanced vigor and sexual desire
  • Strengthened penile erections
  • Skin tanning
  • Mood enhancement
  • Possible improvement in neuropathy

 

 

While side effects of peptides are rare, this peptide can have the effect of causing mild headaches or nausea in about 5-10% of users.  Sometimes flushing can occur as well.  Of course tanning of the skin may be preferred by some but not others

More on Nootropics

Selank and Semax are both nootropics (cognitive enhancer) that were developed in Russia. In some cases, they can be used for similar purposes.  Selank is an anxiolytic peptide that minimizes the harsh effects of stress and it is known to have fewer side effects when compared to Semax.

Selank and Semax are both potentially amazing cognitive enhancers. Semax is more potent in enhancing cognition and depression. Selank, on the other hand, shows better results when used for anti-anxiety purposes.

 

Selank is an anxiolytic peptide, which helps combat stress and anxiety.  A study with a randomized controlled trial of 62 patients found out that those who took Selank had fewer symptoms of anxiety. One promising caveat observed in the same study is the greater decrease in those participants with pre-existing anxiety disorders.

This similar effect was observed in another randomized controlled trial with 60 anxiety and phobia patients.

May Improve Learning Ability

One study in mice showed Selank’s capability to improve learning ability within three days. The subjects treated with the peptide learned quicker on an electrical test.

 

May Help with Brain Damage Recovery

Researchers found Selank to restore the brain activity of mice with toxin-induced brain damage to normal levels.

 

May Help with Blood Pressure Management and Increase Brain Blood Flow

Selank decreased the blood pressure of sedated cat subjects by about 30% for 3 minutes in one study. It also increased the cats’ brain blood flow by about 24% for up to 10 minutes.

 

May Help with Weight Loss

Researchers found that when treated with Selank, high-fat-fed mice gained 35% less weight.

 

Helps Reduce Stress

Stress can be caused by a lot of different things, and the body reacts to it in various ways, as well. For instance, some bodies respond to stress by increasing the production of liver enzymes.  One study conducted on rats showed that Selank reduced liver enzyme production.

May Help with Parkinson’s Disease

Parkinson’s disease is a neurodegenerative disorder characterized by muscular rigidity, slow and imprecise movement, and tremors. Clinical trials found significant results, such as:

 

  • Improved mood
  • Decreased tremors
  • Better sleep quality
  • Decreased tearfulness
  • Lively reflexes

 

Although it contains a stabilizing protein sequence, Selank’s half-life is only two minutes—after 10 minutes, it becomes completely untraceable in the bloodstream. This opens the question of whether the peptide can really have long-lasting effects.  However, doctors using it still find it to benefit patients using it.

Semax has undergone extensive study in Russia and is on the Russian List of Vital & Essential Drugs approved by the Russian Federation government on December 7, 2011. Medical uses for Semax include treatment of stroke, transient ischemic attack, memory and cognitive disorders, peptic ulcers, optic nerve disease, and to boost the immune system.

  • Increased brain BDNF (Brain Derived Neurotrophic Factor) levels and memory
  • one small-scale Russian study in healthy male users, Semax was reported to increase memory and attention during “extreme” or “highly-demanding” tasks. However, the details of this study are not available in English, and so the size and overall significance of these reported effects remain unknown
  • The memory effect may in part be due to mechanisms such as improved brain circulation and increased resistance to oxidative stress.
  • Some research also suggests that BDNF levels can influence mood, and that low levels of BDNF in the brain may be involved in the development of psychiatric conditions such as depression and anxiety.
  • Neuroprotective/cardioprotective activity
  • it may help partially protect the brain from various types of stress and damage, such as from oxidative stress, inflammation, or possibly even adverse cardiovascular events, such as strokes.
  • In rats, Semax has been reported to protect the heart from damage after a stroke or heart attack. This study also reported that the drug may have prevented the excessive growth (hypertrophy) of the heart caused by elevated blood pressure (hypertension), which the authors propose may suggest a protective effect on the risk of additional future cardiovascular events
  • Enkephalins are compounds which are believed to be involved in reducing pain (e.g. by stimulating the brain’s opioid system). Early finding has led some researchers to suggest that Semax may have some potential as a pain reliever by inhibiting the breakdown of enkephalins, although much more research would be needed
  • Semax has been reported to have a number of effects that may potentially be helpful in the treatment of ADHD, such as increasing attention and memory, as well as increasing the levels of a variety of neurotransmitters that are often reported to be lower in patients with ADHD (such as dopamine) .
  • Based on these early findings, some researchers have proposed evaluating Semax as a treatment for ADHD. In fact, some anecdotal evidence suggests that Semax is already occasionally used in Russia for this purpose (even though this medical application has not been officially approved)
  • Affecting the expression of certain genes related to the immune and vascular systems

Cerebrolysin – CerebroPep is by far one of the most well-studied peptides for treating neurodegenerative diseases, let alone as a medical treatment option.  With cognitive decline on the rise, while manifesting in many different types of diseases, it is more imperative than ever to fully optimize our brain health.

A mixture of free L-amino acids and neuropeptides, CerebroPep also contains nerve growth factor, ciliary neurotrophic factor (CNTF), and brain-derived neurotrophic factor (BDNF).   The low-weight neuropeptides are no larger than 10,000 Daltons, which explains why Cerebrolysin can effectively penetrate the blood-brain barrier and directly exert its effects on the brain

Cerebrolysin contains natural neuropeptides that stimulate protein synthesis and neuron growth, support their functions, and help them to communicate with each other.

The peptide restores damaged neurons and slows down neuron damage while protecting them from the onset of unwanted symptoms, which explains Cerebrolysin’s ability to simultaneously tackle multiple domains of neurodegeneration

  • Effective for Cognitive Recovery From Strokes
  • Help speed Up Recovery from Traumatic Brain Injury (TBI)
  • Improves Measures of Cognitive Function in Dementia Patients
  • Can give adjunctive support in Alzheimer’s Disease
  • Might Be a Worthwhile Therapeutic Treatment for Spinal Cord Injury (SCI)
  • May Be Effective in Treating ADD / ADHD
  • Shows Potential For helping Parkinson’s Disease patients improve function
  • May Address Disease complications of Diabetes (cardiovascular disease, organ damage (eyes, kidney, etc.), diabetic neuropathy and impaired mental health.
  • Could Improve Mental Functioning in Autistic Children
  • Demonstrates Cognition-Enhancing Properties

 

Practitioners in the functional medicine community are using quite a variety of peptides in their practice.  I have only presented a few in this article… but you get the picture that they are immensely helpful.  Some report that it has been so helpful that they did not know how they practiced without them previously and that they would never want to not have them available for patient care.

Please Note:

It should be understood that not everyone will experience the benefits associated with the peptides above.  Generally, side-effects are mild and not common, even rare.  So, most individuals will likely have no side-effects at all.

In addition, these peptides are not to be a substitute for sound medical advice and treatment from your PCP.  They are not a treatment for disease but will support the efforts of your body to heal itself.  Your body does all the healing.  Any supportive supplement or peptide will help the body in its efforts but in the end, it is your immune and other systems, given the nutrients that it needs, that actually heals.

These statements have not been evaluated by the Food and Drug Administration. The products mentioned in this article are not intended to diagnose, treat, cure, or prevent any disease.   The information in this article is not intended to replace any recommendations or relationship with your physician.

 

 

Dr. Trubey’s patients with digestive conditions routinely obtain relief from Irritable Bowel Syndrome, Chronic gastritis, and chronic diarrhea. Call for an appointment – 501-538-4944.

 

Anti-Inflammatory Diet

Anti-Inflammatory Diet

More Nutritional Articles

The Anti-inflammatory Diet and Supplement Support

Arkansas Nutrition and Natural Healing

Dr. Roger Trubey, Dr.PH, MPH, and Doctor of Integrative Medicine 362 Unger Trail, Mountain Home, Arkansas 72653

Call 501-538-4944

Chronic Inflammation

A substantial body of scientific information is now linking chronic inflammation to almost all chronic degenerative diseases.  These include the leading killers, cancer, heart disease and stroke as well as diabetes, arthritis, multiple sclerosis, inflammatory bowel disease, fibromyalgia, chronic fatigue and a multitude of others.  In fact many diseases like benign prostatic hypertrophy, are essentially inflammatory by nature and should be treated with an anti-inflammatory diet and natural anti-inflammatory therapeutics.

Inflammation is a normal body process; even the body itself will even produce some of these toxic chemicals to kill pathogens.  But when we take in or produce toxins the body will attempt to rid itself of these. The excretion process through urine, sweat, tears, and cough are some of the ways the body rids itself of toxins.  When this process is inadequate or is overwhelmed with excess toxins, the body will attempt to “burn” out the toxins with inflammation.  When this process is insufficient, the toxins become entrenched in the tissues, the inflammation continues and the process ends in a chronic degenerative disease.

Any inflammation is a message that something is wrong.  And this inflammation that leads to all these diseases is initiated primarily by two sources – microbes, and our typically rotten diets.  In some cases the initiating event is a trauma of some type, emotional or physical, including surgery.  Even chronic allergic reactions may act as a trigger but this usually leads to a microbial infection. Any trauma, surgery or allergic response will cause an increase in white blood cells at the site of tissue damage.  These macrophages in turn produce several pro-inflammatory messenger chemicals called cytokines.  If the inflammatory trigger or the microbial infection continues, or if the body is unable to get the inflammatory response called off, cytokine production continues.  This will result in cellular/tissue destruction, which, by the way, leads to more macrophage production.  If the body loses this battle to “dial down” this inflammation, this cycle continues. The resulting tissue destruction can be extensive and sometimes permanent.

    The Typical Inflammatory Cytokines

  • C-Reactive Protein (CRP)
  • Interleukin 6 (IL6)
  • Tumor Necrosis Factor-alpha (TNF-a)
  • Interleukin – 1 and 8
  • Cyclooxygenase 2 (Cox 2)

Elevated levels of CRP or IL6 dramatically increase one’s risk for heart attack, diabetes or cancer.  Consider the huge over-emphasis conventional medicine has placed on cholesterol levels and realize then the disconnect in the fact that half of all heart attacks occur to people with normal cholesterol. And serious killer plaque is found in people with arteries that are not blocked.

Inflammation Provocateurs
In most every chronic degenerative or autoimmune disease a chronic virus, parasite, bacteria, or similar microbe is present.  When the genome project was completed it was found that 1/3 of our genes are viral genes.  These viral genes can be expressed with a chemical insult.  Considering that the average American body is contaminated with 300 – 500 different chemicals, it is not too difficult to see how easy it would be for the expression of a virus and the onset of an inflammatory response.  In this case the virus is not coming from outside to within but originates from within.  The role of infection in heart disease is well documented in the scientific literature, but likewise with arthritis and a host of others.  Unless these pathogens are eliminated or in the case of viruses, the chemical provocateurs excreted, they will continue to act as an inflammatory mediator and continue to promote the inflammatory cycle described above. These really must be tracked down and eliminated and the sources for re-entry greatly reduced.

Changing Our Diets
While pathogens or traumas via the inflammatory response are indeed involved in most all chronic diseases, the most pervasive factor under girding this is the Standard American Diet (SAD).  Our SAD diets are typically loaded with inflammatory fats, processed foods and really junk foods.  Consider that the number one source of calories in the American diet is soft drinks.  This used to be white flour/bread, so we are not making any progress whatsoever.  The consumption of doughnuts, pastries, potato/corn chips, burgers, cookies, candy and the like are indeed, well designed to produce inflammation in our bodies.

So what in our diets has to change?  We have to decrease the excess consumption of pro-inflammatory omega 6 fats (oils from corn, soy, safflower, etc) along with the omission of all trans fats and hydrogenated fats (found in margarine, mayonnaise, crackers, cookies, chips, and in fact almost all processed food).  We also have to increase anti-inflammatory omega 3 fats (cold-water fish/fish oil, and to a minor extent flax) that are way under-consumed compared to the omega 6 oils.Any liquid oil that is exposed to heat, light or air will begin to oxidize and become partially rancid, unfit for consumption. Since every cell of our body has a lipid (fatty) membrane, these damaged fats, along with the excess undamaged omega 6 fats, will become a part of the cellular structure where they will participant in the inflammatory cascade.

Remember, inflammation is not necessarily bad in and of itself.  It becomes a problem when it becomes like an accelerator in a car that gets stuck and the brakes (omega 3 fats) are inadequate.  When the balance of the omega 6:3 ratio shifts excessively in the omega 6 direction, we create an inflammatory pump just waiting for a trigger to flip the “switch”.

Here is an example of how we do this.  Beef used to come from animals that were almost exclusively grass-fed (exactly what they were designed to eat).  Now, the epitome of a great steak is one from corn-fed beef.  But when we consume corn-fed beef instead of grass-fed beef, we change the omega 6:3 ratio from 1:1 in grass-fed beef to 16:1 in corn-fed beef-a dramatic increase in the pro-inflammatory direction.  The same shift occurs in chickens and their eggs when we cage them as opposed to free-range hens and eggs.  Some estimate that we consume as much as twenty times the amount of omega 6 fats as we should, compared to the amount of omega 3 fats.

Dietary Recommendations –  Eat Whole, Natural foods
The following dietary/supplement guidelines are contraindicated if you are on a blood thinner such as coumadin and are not to supplant the specific advice of your physician.

  • Use only red meats such as grass-fed beef or buffalo but never in excess.  Omit all processed meats such as bacon, sausage, deli meats etc.
  • Use eggs, chickens and turkeys for consumption that have been allowed free-range.  Not generally found at commercial grocery stores where eggs are at least 1 month old.
  • Protein from wild Alaskan salmon, halibut or other cold-water fish is encouraged; but use only wild, uncontaminated sources.  Most fish today, including fresh water fish, are contaminated with mercury, PCBs or dioxin.  Farm-raised salmon (about 2/3 of the US market) should never be used.
  • Omit all refined carbohydrates and high glycemic foods from white flour, white sugar, white rice, etc.  These foods are nutritionally depleted and convert to sugar rapidly (high glycemic).  Other high glycemic and problem foods include potatoes, breakfast cereals, muffins, crackers, cookies, etc.  One anti-aging specialist finds that high glycemic foods may be responsible for 50% of skin aging caused by sugar molecules reacting with collagen and releasing cell damaging free radicals that will induce an inflammatory chain of events.
  • Reduce significantly all deep/fried foods and food requiring high temperatures including, French fries, corn/potato chips, burgers, fried chicken, pizza, doughnuts.  Fried foods and foods held at high temperatures will produce Advanced Glycation End products (AGEs) whereby a sugar molecule binds to a cell protein.  The damaged proteins accumulate and will stimulate the production of inflammatory cytokines.  In addition the fats in some of these foods may be more than 1/3 trans fats.
  • Eliminate beverages containing refined sugars, high fructose corn syrup or artificial sweeteners (including Splenda and Aspartame or NutraSweet).  These include sodas, most bottled teas, diet sodas and most fruit juices.  All of these will encourage the inflammatory process.
  • Do consume 4 -6 servings of anti-inflammatory, green or yellow vegetables daily.
  • Fruits can be an excellent source of anti-oxidants especially highly colored ones.  The best fruits to consider that are low glycemic and anti-oxidant rich are cherries, berries, apples, pears and red grapes.
  • Nuts, seeds and legumes are low glycemic and most nuts and some seeds have some healthy fats including some omega 3s.
  • The best cooking oils are olive, coconut, and grape seed oil.  Do not use oils from soy, corn, sunflower, safflower etc.

 

Anti-inflammatory Supplements to Consider

    • Always use digestive enzymes to adequately digest your food.  Plant-based enzymes before meals are preferred.  Most individuals with autoimmune or other chronic disease will benefit from potassium-activated hydrochloric acid to fully digest food, support the stomach and immune system and decrease intestinal inflammation.

 

    • probiotic (friendly bacteria) naturally assists the enzymes in improving gut health and controlling intestinal inflammation.

 

    • Omega 3 fish oils are an essential component of any anti-inflammatory program.  Fish oils in the range of 2-3000 mg/day (or higher in some cases) have been found to significantly suppress inflammatory cytokine production.  Be sure the total consumed is for the combined amount of EPA and DHA only, not the total amount of fatty acids in the capsule or liquid.  And be sure it is free of toxic contaminants as well.

 

    • Gamma Linolenic acid (GLA), 250 – 350 mg of GLA/day can also promote a reduction in inflammation.  Sources of these include, Borage oil, Black Current Seed oil, or Evening Primrose oil (preferred).

 

    • Proteolytic enzymes from natural (plant or animal) sources can have a significant benefit in pain syndromes and inflammation reduction.  They can improve blood flow and breakdown immune complexes (inflammation) in auto-immunity.  Possible sources include:  Bromalin (pineapple source), 1200-2400mg/day; Marcozyme or Wobenzyme (multiple enzymes of plant/animal sources), 4 –12 tablets/day on empty stomach; Nattokinase (best for cardiovascular and plant source), 100 – 200 mg/day; Serratiopeptidase (from silk moth) 10 – 30 mg/day.

 

    • Anti-inflammatory herbs can be of significant help in alleviating inflammation.

 

      • Turmeric (best choice all-around/active component is curcumin) 600 – 1200 mg/day
      • Ginger root 300 – 600/day
      • Garlic – in capsules use the allicin equivalent to 1 ½ cloves/day
      • Boswellia Serrata, 500 – 900 mg/day
      • Devils Claw, Cats Claw, Green tea and Cayenne pepper – consider these also
    • Anti-oxidant support may have considerable impact on CRP and other cytokines and will decrease inflammation

 

      • Vitamin C, 1-2 gm daily with higher doses in some cases
      • Vitamin E (including D-alpha and D-gamma Tocopherol) 400 – 800 IU with higher doses in some cases
      • Alpha Lipoic Acid (ALA) 500 –1200 mg/day or best DHLA Nano-Plex (a reduced form of live-source ALA) ¼ – ½ tsp 2X/day.  DHLA can significantly reduce lipid peroxides, the destructive promoters of chronic degenerative, inflammatory diseases.

 

    •  
    • General Recommendations

 

    •  Get adequate sleep.  Sleep deprivation will increase inflammatory cytokines and cortisol significantly
    • Use as much organic food as possible.  Pesticides, herbicides, act as inflammatory toxins
    • Be cautious about what you put on your skin – what you apply to your skin you eat!  Would you eat Deep Woods Off?  How pure are your cosmetics?  Does your antiperspirant contain aluminum?
    • Be cautious about what you spray or smell such as spray paints, insect spray, week killers, perfumes, etc. the list is endless.  We live in a rather toxic world.
    • Reduce your weight if necessary.  Fat cells are a significant source of inflammatory cytokines.
    • Reduce stress/anxiety as it will directly lead to increase the inflammatory process

Adrenal and Sex Hormone Assessment

Adrenal and Sex Hormone Assessment

Natural Health Services

Adrenal and Sex Hormone Assessment

Arkansas Nutrition and Natural Healing

Dr. Roger Trubey, Dr.PH, MPH, and Doctor of Integrative Medicine 362 Unger Trail, Mountain Home, Arkansas 72653

Call 501-538-4944

Hormones exert a powerful influence over all physical, intellectual and emotional behavior. Problems with weight, memory, sleep, digestion, blood pressure, high cholesterol, cravings, addictions, sexual dysfunctions, and problems associated with the immune system, are all influenced by the endocrine system. Endocrine problems lead to a wide spectrum of symptoms that in most cases can be reversed using natural methods.

A primary marker of the aging process in both men and women is a reduction in normal hormone levels which is responsible in large part for infertility, decreased energy and muscle strength, loss of libido, depression, mood swings, inability to cope, and an increase in the symptoms of PMS and menopause.  Research has shown that the use of natural hormone replacement can provide benefits for both men and women.

Estrogen dominance is a primary cause of almost all female health problems, including fibrocystic breast disease, PMS, mood swings, excessive bleeding, endometriosis, fibroids, infertility, and ovarian cysts. Perimenopause is the time when hormone levels begin to shift in preparation for menopause. It is not so much the decrease in hormones that produces the uncomfortable symptoms associated with perimenopause, but rather the changing ratio between estrogen and progesterone. Chronic or episodic depression, severe mood swings, and anxiety are frequent manifestations of these midlife fluctuations.

But estrogen can also be found deficient in the female body as well.  Signs of estrogen deficiency include: hot flashes, night sweats, dry eyes, vaginal dryness, sagging breasts and loss of breast fullness, mental fogginess, depression, changes in mood, decreased sense of sensuality and sexuality.

Progesterone is another female “sex” hormone, produced in the ovaries, that prepares the uterus for a fertilized egg. Its sudden withdrawal causes the uterus to shed its lining if pregnancy does not occur. While estrogen is high (during days 7-14 of the menstrual cycle), progesterone is at its lowest level. Its levels climb to a peak between days 14 – 24, and then dramatically drop off again just before the start of menstruation. Ideally, women should have five to ten times more progesterone than estrogen in the blood and 40 to 150 times more in the saliva. The lower the ratio of progesterone to estrogen, the higher the risk of health problems. Progesterone has the unique ability to change its structural form to become other hormones, allowing it to be converted and utilized by the body to the point of depletion.

Testosterone is responsible for much more than defining sexual characteristics in men or influencing sex drive. Testosterone is essential for life since it helps to regulate basic metabolism. Testosterone also facilitates protein synthesis and the building of body and bone tissues. Testosterone is produced by small groups of specialized cells within the testicles and is also secreted, to a lesser extent, by the ovaries. The production of testosterone is triggered by luteinizing hormone (LH), produced in the pituitary gland. In the absence of LH, testosterone production ceases. With age, blood levels of testosterone slowly decrease. Research conducted by the National Institute of Health has shown a 2% reduction per year from age 30 to age 70.

Endocrine problems may be the result of stress. Simply put, stress is the sum total of all mental and physical input over a given period of time. The marker used to measure stress is the adrenal steroid hormone, cortisol. Stress, whether physical or emotional in origin, provokes a response by the adrenal glands. Many hormonal imbalances are the direct result of adrenal insufficiency. When the adrenal glands become exhausted due to overwork, adequate levels of the stress hormones, DHEA and cortisol cannot be produced, this in turn plays a major role in the usage, or the misappropriation of all the other steroid hormones.  In other words with undue, long-term stress the body will use sex hormones to make stress hormones.  This is never an efficient system and was only designed by the creator for emergencies.  The trouble is that when this process continues for long periods of time, a maladaption takes place that depletes both progesterone and testosterone leading to estrogen dominance and all the problems associated with that in both men and women.

The adrenal glands produce two primary hormones, DHEA and cortisol. Both are considered the major shock absorber hormones in the body. They buffer us to stress and the negative impact it can have on both mental and physical function. Long-term stress can have a serious impact on the adrenal glands and cause them to shrink and reduce production. This causes cellular damage, which sets off a chain reaction affecting all parts of the body, as well as accelerating the aging process.

The adrenal glands hold the key to the hierarchy of hormones. It is necessary to establish the proper foundation first which means you must determine the cause of the hormonal dysfunction and treat the cause first. Our research has shown that to cause a positive hormonal change you must normalize adrenal activity first. It is the mainspring in the hormonal mechanism. When the adrenals malfunction, all other associated systems will as well. The symptoms associated with adrenal dysfunction are diverse and can involve the digestive, circulatory, respiratory, as well as the brain and nervous systems. In addition, the adrenals can impact the growth and repair of bones, muscles, hair and nails.

 

Knowing your adrenal and sex hormone levels is an important first step in assessing where your hormones may be out of balance and determining whether your current natural hormone regimen is working for you. If you are wondering whether certain symptoms may be due to a hormone imbalance, this is a quick, easy, and accurate way to find out.

There are three primary ways of assessing hormone levels – blood, saliva and urine. While each some advantages and disadvantages, it is my opinion that overall the best method is urine. But some testing will combine the saliva and urine and some parameters are only assessed via blood.

Saliva testing – While the free cortisol pattern in saliva has clinical value, there is a significant missing piece to surveying a patient’s HPA-Axis function with saliva testing – measuring metabolized cortisol. To properly characterize a patient’s cortisol status, free and metabolized cortisol should be measured to avoid misleading results when cortisol clearance is abnormally high or low. Likewise with sex hormones, measuring estrogen and androgen metabolites gives a fuller picture for more precise clinical diagnosis of hormonal imbalances and HRT monitoring.

Serum testing – While the most universally accepted testing method (due to the availability of FDA-cleared analyzers that are reliable and inexpensive), serum testing is lacking in some areas. Adrenal hormones cannot be effectively tested in serum because free cortisol cannot be tested throughout the day. There is also a lack of extensive metabolite testing (especially for cortisol and estrogens).

24-Hour Urine Testing – There are two primary drawbacks to urine testing of hormones. First, the collection is cumbersome, and as many as 40% of those who collect, do so in error. Secondly, dysfunction in the diurnal pattern of cortisol cannot be ascertained from a 24-hour collection. The daily free cortisol pattern was formerly only available with salivary testing.

The Dried Urine Test for Comprehensive Hormones (DUTCH) offers some distinct advantages.

· This advanced hormone testing was developed to improve on the available hormone testing options. DUTCH offers the most extensive profile of sex and adrenal hormones along with their metabolites. Additionally, the daily (diurnal) pattern of free cortisol is included along with melatonin. This unique combination of clinical information is not available by any other method.

· Effective HRT Monitoring: DUTCH testing was specifically made to be optimally effective for most forms of hormone replacement therapy. Unique methods are used for improved monitoring of oral progesterone and vaginal hormones.

· The Easiest Patient Collection: Patients collect just four or five dried urine samples over a 24-hour period. Dried specimen shipments are convenient worldwide. Dried samples are stable for several weeks.

· Analytical and Clinical Validation: Precision Analytical testing methods go through a rigorous validation process to verify accuracy, precision, recovery, linearity, etc.

In a separate test the lab providing the DUTCH assessment also combines the regular DUTCH urine assessment with saliva testing as a means of assessing a Cortisol Awakening Response (CAR). CAR is the natural rise in cortisol that is seen 30 to 40 minutes after awakening followed by a noticeable drop by 60 minutes. This activity is influenced by brain activity (hypothalamus/pituitary) and by adrenal function. Stress of all types will have a major influence on the CAR response.

Lower than normal CAR is often seen in individuals with:

· A high amount of psychosocial burnout

· Chronic fatigue

· PTSD

· Seasonal affective disorder (during winter)

· Nightshift work schedules

· Sleep apnea

· Short sleep cycles

· Chronic inflammation

· Adrenal insufficiency

· Lack of morning sunlight exposure

· Hippocampal damage or atrophy

· Amnesia (due to temporal lobe damage)

 

Factors associated with an elevated CAR include:

· Immediate access to light upon awakening

· Depression

· Ovulation phase of the menstrual cycle

· Sleep issues

· Older age

· Ongoing job-related and perceived stress (CAR is significantly higher on work days)

 

Hormone testing provides clues about menstrual irregularities, infertility, erectile dysfunction, endometriosis and osteoporosis. A hormone test can determine some of the reasons for hot flashes, night sweats, decreased libido, as well as monitor bio-identical and natural hormone therapy. In addition The DUTCH assessment also provides you a number of other very important clinical health parameters including:

· Methylation activity on hormones

· Vitamin B6 and B12 markers

· Glutathione marker

· Neurotransmitter metabolites

· Melatonin levels

· 8-OHdG Oxidative stress level

· Phase I and II detox function

 

Saliva contains the free fraction of the hormones which reflects the bioactive tissue levels. Free Fractions in saliva correlate more closely with clinical symptoms than total blood serum hormone levels (which mostly reflect the bound fraction). But dried urine testing has been shown to be extremely well correlated with saliva levels while at the same time providing us with many additional parameters that are unavailable with either saliva or blood.

Adrenal and sex hormone assessment is an accurate and simple way for you to know your current status of both the adrenals and sex hormones giving you information you will find highly valuable to improving your overall health.

 

Call Dr. Trubey at 501-538-4944 and make an appointment for a comprehensive health evaluation today.

Toxic Metal Evaluation

Toxic Metal Evaluation

More Nutritional Articles

 

Toxic Metal Evaluation

 

Arkansas Nutrition and Natural Healing

Dr. Roger Trubey, Dr.PH, MPH, and Doctor of Integrative Medicine 362 Unger Trail, Mountain Home, Arkansas 72653

Call 501-538-4944

Urine heavy metal analysis is an invaluable tool for the assessment of retention of toxic metals in the body.  Toxic metals in the body do not have any useful physiological function, adversely affect nearly every organ system and disrupt the homeostasis of nutrient elements.

Blood levels of toxic minerals are unreliable indicators of the actual body burden.  They are trapped within the tissues of the body where they replace nutritional minerals in critical areas and poison cellular function.   The body has a difficult time excreting these toxic metals and over time can accumulate to higher and higher levels.  Individuals will vary in their ability to eliminate these metals and will also vary in their individual sensitivity to the toxic effects of these metals.  Due to this variability of sensitivity and excretion capacity, it is difficult to predict how individuals will be affected when exposed to heavy metals and whether it is a factor in the symptoms and dysfunction of each patient.  What we do know is that it is very common to find toxic metals like lead, aluminum, mercury, barium, cadmium and arsenic, among others, when testing.

Most conventional physicians do not accept the concept of chronic metal toxicity as a cause of chronic degenerative disease.  While they recognize and accept acute poisoning by toxic metals, they fail to appreciate how many of their patients are severely burdened with a buildup of toxic metals over time and the role they play in their patient’s health problems.  Acute poisoning by metals and chronic exposure will present very different symptom pictures.

When acutely poisoned, a person will have the metal present in the blood and urine.  However the body will rapidly distribute the toxic metals into safer areas in the tissues and they will no longer be detectable in either blood or urine.  When acutely poisoned with toxic metals, an individual is critically ill and needs chelation treatments immediately.  When poisoned more slowly over time, an individual can become chronically ill and often has just as much need to remove these metals to improve their health as well.

When evaluating for heavy metal toxicity, patients use a rectal suppository of EDTA and a few capsules of DMSA taken orally.  Both EDTA and DMSA are chelators that have a strong affinity for toxic metals and bind them with sufficient strength to adequately remove them from the tissues and induce their elimination mostly through the urine but to a smaller extent through the stool.  An overnight urine collection is then sent to the laboratory for evaluation of the various metals.  Both chelators have a long history of safe and effective use in the removal of toxic metals. If there is a need for additional chelators to clear out heavy metals we are not without alternatives. These can be in addition to or in place of the above. NDF is an excellent binder of metals and even a good Vitamin C and Glutathione are excellent binders and removers of metals, although generally a bit slower. Lypospheric Vitamin C and Lipospheric Glutathione I would highly recommend. Glutathione is the powerful intracellular antioxidant absolutely critical for good health. For most individuals the problem is that toxic metals are coming in faster than the body is able to get rid of them.

 

Call Dr. Trubey at 501-538-4944 for an examination. Comprehensive health evaluation to include metal toxic poisoning testing.

Nutritional Therapy

Nutritional Therapy

Vitamin, Mineral and Nutrient Assessment

Arkansas Nutrition and Natural Healing

Dr. Roger Trubey, Dr.PH, MPH, and Doctor of Integrative Medicine 362 Unger Trail, Mountain Home, Arkansas 72653

Call 501-538-4944

Overwhelming scientific evidence confirms that vitamin and mineral deficiencies are associated with disease processes and the overall condition of one’s health. Vitamin, mineral and antioxidant deficiencies have been shown to suppress immune function and contribute to chronic degenerative processes such as arthritis, cancer, Alzheimer’s, cardiovascular disease and diabetes. This body of research has been reaffirmed by the Journal of the American Medical Association (June 19, 2002-Vol 287, No 23).

I use the Micronutrient testing provided by SpectraCell Laboratories.  This patented process resulted from 18 years of research at the University of Texas. The micronutrient tests measures how vitamins, minerals and other nutrients are actually functioning within your white blood cells. These tests allow me to provide an objective nutritional assessment for a broad variety of clinical conditions including arthritis, cancer, cardiovascular risk, diabetes, various immunological disorders, metabolic disorders and micronutrient deficiencies. Through SpectraCell we can also assess one’s Lipoprotein Particle Profile, a specialized profile of homocysteine, lipids and proteins to assess cardiovascular risk. .

Before the introduction of intracellular testing, many diagnosis and risk assessments were based on clinical observation and measurements of static levels of certain nutrients in serum. Static serum levels are commonly not representative indicators for assessing cell metabolism and utilization.  A functional evaluation of nutrients, like that offered by Spectracell, offers a unique means to scientifically assess the intracellular requirements of our nutrients that play an important role in our overall health and wellness. These tests measure the biochemical function of vitamins, minerals, amino acids and antioxidants, providing a powerful clinical assessment tool that provides you with very specific information regarding any deficiency of nutrients that you may have.  This assessment of your vitamins, minerals and other nutrients is designed to provide you with the most objective nutritional analysis available. .

The test also provides each patient a total antioxidant evaluation (SPECTROX™), which assesses the ability of cells to resist damage caused by free radicals and other forms of oxidative stress. Due to the considerable number of cellular antioxidants with extensive interactions, redundancies, repair and recharging capabilities, measuring total function is the most accurate and clinically useful way to assess your body’s capacity to resist oxidative damage.  Given that we are continually exposed to a huge variety of oxidants – toxic metals, chemicals, pesticides, biological agents etc – our need to protect ourselves from this onslaught is critical.  This part of the test will evaluate exactly how well your body is able to do just that..

Nutritional Therapy

The Nutrients tested in the Vitamin, Mineral and Nutrient Assessment:

VITAMINS

Vitamin A
Vitamin B1
Vitamin B2
Vitamin B3
Vitamin B6
Vitamin B12
Biotin
Folate
Pantothenate
Vitamin C
Vitamin D
Vitamin K

MINERALS

Calcium
Magnesium
Zinc
Copper

Amino Acids

Asparagine
Glutamine
Serine

Antioxidants

Alpha Lipoic Acid
Coenzyme Q10
Cysteine
Glutathione
Selenium
Vitamin E

Spectrox™

for Total Antioxidant Function

Carbohydrate Metabolism

Chromium
Fructose Sensitivity
Glucose-Insulin Metabolism

Fatty Acids

Oleic Acid

Metabolites

Choline
Inositol
Carnitine

 

To be sure, there are other means of assessing ones nutrient status. But the above is the most objective assessment means available.

Call Dr. Trubey today at 501-538-4944 to test whether Vitamin Mineral Deficiency is suppressing your immune function and contributing to a poor health condition.